Proton pump inhibitors in the treatment of gastroduodenal ulcer bleeding: optimization of drug therapy methods

Currently, peptic ulcer disease remains the most common of digestive system. Ulcerative bleeding is a terrible complication. The main condition for successful conservative treatment gastrointestinal that occurs against background acid-dependent diseases adequate acid-reducing therapy. We conducted study comparing different modes administration proton pump blockers. To this end, three groups were formed: first group: drug Rabeprazole was obtained as an antisecretory dosing regimen consisted in introduction bolus 80 mg, then constant infusion at rate 8 mg per hour 72 hours, after which transfer to oral form 20 ×2 times day; second received rabeprazole intravenously dosage 40 2 third day ×twice day. use PPIs various dosages significantly reduced risk relapses and deaths. have shown also effective method treating patients with ulcerative gastroduodenal bleeding.